Introduction
Ozone therapy is a complementary medical treatment that uses a controlled mixture of ozone (O₃) and oxygen (O₂) to improve oxygen utilization, reduce microbial load, and support tissue healing.
It is used in integrative, naturopathic, and regenerative medicine for its antimicrobial, anti-inflammatory, and immunomodulatory effects
Different forms include:
- Major Autohemotherapy (MAHT) – most common systemic method
- Minor Autohemotherapy
- Rectal Insufflation
- Topical Ozone/Ozonated oils
- Ozone Sauna (HOCATT)
- Ozone injections (Prolozone)
Procedure
a. Major Autohemotherapy (MAHT) – Systemic Method
- Patient sits or lies comfortably.
- A measured amount of blood (usually 50–200 ml) is drawn into a sterile ozone-resistant bottle.
- Medical-grade ozone–oxygen mixture is introduced at a specific concentration.
- The blood is gently mixed and then reinfused into the patient.
- Entire session lasts 20–40 minutes.
b. Rectal Insufflation – Non-invasive Method
- Patient lies in left lateral position.
- A small catheter is inserted 2–3 cm into the rectum.
- Low-volume ozone gas mixture is introduced slowly.
- Acts as a systemic treatment through absorption via the colon.
c. Local Applications
- Ozonated oils/creams
- Ozone bagging for wounds
- Ozone steam sauna
Benefits
- Antibacterial, antiviral, antifungal effects
- Improves oxygen delivery to tissues
- Reduces inflammation in chronic inflammatory conditions
- Enhances wound healing (diabetic ulcers, infected wounds)
- Modulates immune response
- Pain reduction in musculoskeletal conditions (via Prolozone injections)
- Improves circulation and microvascular function
- May assist in detoxification by reducing oxidative stress when administered properly
- Supportive in chronic conditions like fatigue, infections, ischemic diseases (adjunct therapy)
Contraindications
- G6PD deficiency
(Risk of hemolysis when exposed to oxidative therapies) - Active pregnancy
- Uncontrolled hyperthyroidism
- Significant bleeding disorders
- Recent myocardial infarction
- Ozone allergy/sensitivity (rare but reported)
- Severe cardiovascular instability
- Severe anemia
- Acute alcohol intoxication
- Febrile illness
- Patients on blood thinners (need dose adjustment)
- Chronic obstructive pulmonary disease (for inhalation risk—ozone should never be inhaled)